White Papers

HAnano Surface is well-documented with numerous publications in peer-reviewed journals as well as internal test protocols. The key results have been summarized in the following White Papers.

Research Monograph – July 2023

The July Edition of our HAnano Surface Research Monograph features studies demonstrating the biomimicking, hydrophilic, bioactive and osteoconductive properties of the nano-sized hydroxyapatite crystal layer. The studies show a faster and improved osseointegration, as well as improved performance in compromised bone.

Within our research monograph series, we publish selected summaries of the latest scientific results.

Increased Fixation and Integration of Titanium

Osseointegration is (to a considerable extent) dependent on the implant surface. To evaluate the effect of HAnano Surface on different surface roughnesses, three different in vivo studies with HAnano Surface modified and unmodified implants were evaluated.

The aggregated results from these studies clearly demonstrate that HAnano Surface facilitates and enhances the osseointegration process during the early phases of healing. The enhancement can be seen regardless of the underlying surface roughness. It is also shown that the roughness itself is not affected by the application of HAnano Surface. Thus, HAnano Surface can be applied to a range of implants – with rough to smooth surfaces – to accelerate and enhance osseointegration.

Excellent Adherence to Any Material, Any Structure

Traditional hydroxyapatite coatings form thick layers on the implant surface that are easily damaged when the implants are inserted. Compared to traditional coatings where bone anchors to the coating, HAnano Surface does not act as an interface separating bone from the implant. Since HAnano Surface is particle-based there is no risk of cracking or delamination of the implant.

Unmodified and HAnano Surface modified titanium, ceramic, and PEEK implants were evaluated prior to and after implantation into a cortical bone model with Scanning Electron Microscopy. The result showed that the hydroxyapatite crystals still covered the entire implant surface after removal. This shows that HAnano Surface is well-adhered to PEEK, ceramic and titanium surfaces.

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implant surface modification


Promimic is specialized in nanotechnology and production of hydroxyapatite.

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dental implant surface enhancement and osseointegration

Products and Technology

The wet chemical technology behind HAnano Surface can be used on all types of implants in the orthopedic, spinal and dental fields.

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