Master’s Thesis – Antibiotic adsorption to ultrathin ceramic surfaces and its antibacterial effect, spring 2025
Bacteria living on surfaces are called biofilms, and they cause up to 80% of all infections. They are difficult to eradicate using systemic antibiotic treatment, and if present on an orthopedic implant surface they can ultimately cause implant rejection. Biofilm formation and infections can be prevented by the distribution of antibiotics on the implantation site, or directly onto the implant. To ensure antibiotic effectiveness and to minimize the risk of antibiotic resistance, control of the dosage is very important.
Aim
This project aims to investigate how different substrates affect the adsorption and resorption kinetics of antibiotics. Titanium substrates treated with different types of nanosized ceramic coatings, will be exposed to antibiotics and the adsorption and resorption kinetics will be measured with spectrophotometric methods. Gram negative bacteria as well as multispecies consortia will be allowed to form biofilms for different time periods. The biofilms will be analyzed with well-established microbiological methods to assess the effect of surface adsorbed antibiotics.
- We are looking for a candidate with a background in Biotechnology and/or Microbiology
- Who learns fast, can work independently, is motivated and a team-player
- With fluency in English
- Who is proficient in Microsoft Word and Excel
- With previous lab work experience (including experience from University)
Who are we?
Promimic’s nanotechnology, HAnano Surface, creates a unique bioactive surface on any implant. The HAnano Surface has demonstrated faster and stronger osseointegration in over 30 clinical studies, with over 1.4 million clinical applications to date.
The HAnano Surface is a 20 nanometer thin implant surface treatment composed of crystalline hydroxyapatite (HA) particles, which have the same shape, composition, and structure as HA found in human bone.
We are located in GoCo Health Innovation City in Mölndal, easily accessible by car, bike or bus from Gothenburg.
What can we offer?
Promimic offers a hands-on research opportunity in the field of nano-surface technologies and material surfaces. As part of our team, students can contribute to cutting-edge projects that focus on enhancing the performance of medical implants. This involves applying theoretical knowledge to develop innovative solutions, with access to specialized labs, equipment, and resources not typically found in academic settings. It’s a chance to contribute meaningfully to healthcare advancements while gaining practical experience in a real-world application. Compensation is included.
Apply by sending your cv and cover letter to maria.holmstrom@promimic.com.